Finding what people are really interested in is difficult. Newspapers don't discuss what people are obsessed about. They merely "collect" discrete news and consolidate them together in a paper.
Twitter Trends are topics twitters mostly talk about. You really want to see what people are talking about? Check twitter trending topic. You can see the current , daily or weekly trends.
I noticed that after I integrated Twitter Trends with YouTube into what I called "TwitTube"
Now you've got a list of HOT topics, pick one and start a niche on.
That's pure Web 2.0